Cardinals vs 49ers matchup
The gist
The 49ers host the Cardinals on Sept. 27 as 8.5-point favorites with Nick Bosa ruled out.
San Francisco can start 3-0, but Bosa's calf injury tests the defense.
How it unfolded
- Sep 21, 2025Cardinals linebacker Mack Wilson broke up a pass to 49ers tight end George Kittle during a game at Levi's Stadium.
- Nov 2025Brock Purdy led the 49ers to a 41-22 win over the Cardinals.
- Sep 21, 2026The Cardinals and 49ers were scheduled to meet Sunday, Sept. 27, at Levi's Stadium in NFL Week 3.